N-Methyl-D-glucamine 6284-40-8

Whether you are looking for bulk factory direct supply or customized packaging solutions, AECOCHEM ensures that every batch of Meglumine meets strict SOPs and international quality standards. We proudly serve industry leaders like BASF, Brenntag, and Merck, offering efficient logistics and professional analytical support.

Properties：

Melting point: 129-131.5 °C(lit.)

Alpha: -16.5 º (c=10, H2O, on dry sub)

Boiling point: 331.88°C (rough estimate)

Density: 1.2669 (rough estimate)

refractive index: -16.5 ° (C=2, H2O)

storage temp.: Store below +30°C.

Solubility: H2O: 0.1 g/mL, clear, colorless

form : Crystalline Powder

Pka: pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)

Color: White to almost white

PH: 11 (10g/l, H2O, 20℃)

optical activity: [α]20/D 16.5±0.5°, c = 2% in H2O

Water Solubility: 100 g/100 mL (25 ºC)

Sensitive: Air Sensitive & Hygroscopic

Specification:

Appearance: White crystalline powder

Melting point: 128℃-132℃

Residue on ignition: 0.1% max

Loss on drying: 1.0% max

Content: 99.0-100.5%

Specific rotation: -15.7º to -17.3º

Heavy metals: 20ppm max

Absence of reducing substance: Blue don't change to red

Completeness and color of the solution: 0.03% max

What is N-Methyl-D-glucamine (CAS 6284-40-8)?

N-Methyl-D-glucamine 6284-40-8, commonly known as Meglumine, is a white to slightly yellow-colored crystalline powder derived from sorbitol. It is characterized by its odorless nature, high water solubility, and hygroscopic properties. As a versatile amino sugar, it plays a critical role as an organic base in various industrial and medicinal syntheses.

At AECOCHEM, we provide N-Methyl-D-glucamine 6284-40-8 with a purity range of 99.0%–100.5%, ensuring it meets the rigorous demands of pharmaceutical intermediates and contrast media production.

What is N-Methyl-D-glucamine Used For?

The versatility of Meglumine makes it an essential component across multiple high-tech sectors:

1. Pharmaceutical Excipient

It is widely used as an excipient to improve the solubility and stability of acidic drugs. By forming meglumine salts, it enhances the bioavailability of active pharmaceutical ingredients (APIs).

2. Contrast Agents

In medical imaging, it is used in conjunction with iodinated organic compounds to create contrast media such as Diatrizoate Meglumine and Iodipamide Meglumine, essential for clear X-ray and diagnostic procedures.

3. Brain Slice Preparation (NMDG)

In neuroscientific research, N-Methyl-D-glucamine 6284-40-8 (often referred to as NMDG) is substituted for sodium ions in artificial cerebrospinal fluid (aCSF) to maintain the health and longevity of brain slices during electrophysiological recordings.

4. Ion Exchange Resins

Meglumine is highly effective in functionalizing ion-exchange resins, specifically used to selectively chelate and remove boron ions from water and industrial solutions.

5. Catalyst & Synthesis

It serves as a mild base catalyst and a building block in the synthesis of surface-active agents (surfactants), dyes, and specialized pharmaceuticals like Flunixin Meglumine and Methylglucamine Antimonate.

Key Advantages of Choosing AECOCHEM Meglumine

Our N-Methyl-D-glucamine 6284-40-8 offers distinct advantages for industrial procurement:

• Pharmaceutical Solubility & Stabilization: It acts as a superior pH adjuster and buffering agent, preventing the degradation of sensitive pharmaceutical compounds.
• High Solubility & Stability: With a water solubility of 100g/100mL at 25°C, it is ideal for liquid formulations and high-concentration diagnostic agents.
• Environmental & Chemical Engineering: Its unique structure allows for high selectivity in boron removal, making it a "green" choice for water purification.
• Physiological Buffer: Due to its pKa of approximately 9.39, it provides excellent buffering capacity in biological environments.
• Biocompatible Ingredient: Its low toxicity and established safety profile make it a preferred choice for cosmetics and skin-care formulations as a neutralizer.

Frequently Asked Questions (FAQ)

What are the primary physical properties of N-Methyl-D-glucamine 6284-40-8?

It is a crystalline powder with a melting point of 128℃-132℃. It is air-sensitive and hygroscopic, requiring storage in a cool, dry place. Its pH in a 10g/L water solution is approximately 11, reflecting its nature as an organic base.

What is the difference between API standards (API 600 vs 602 vs 603)?

While N-Methyl-D-glucamine 6284-40-8 is a chemical raw material/excipient, it is often used in systems requiring industrial valves. API 600 covers heavy-duty bolted bonnet steel gate valves, API 602 covers small forged steel valves (usually for high pressure), and API 603 covers corrosion-resistant (stainless steel) valves often found in chemical processing plants where Meglumine is handled.

What types of packaging and connections are available for bulk orders?

As a factory-direct supplier, we offer standard 25kg/drum packaging. However, we also provide customized packaging to suit your specific production line needs. For large-scale chemical integration, we ensure our logistics support seamless "one-stop" delivery to your facility.

Ready to optimize your supply chain?
Contact AECOCHEM's English-speaking representatives today for a quote on N-Methyl-D-glucamine 6284-40-8.

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